An introduction to and survey of biological network visualization | TU Wien

Information

Publication Type: Journal Paper (without talk)
Workgroup(s)/Project(s):
- Visualization Group
Date: February 2025
Article Number: 104115
DOI: 10.1016/j.cag.2024.104115
ISSN: 1873-7684
Journal: COMPUTERS & GRAPHICS-UK
Pages: 31
Volume: 126
Publisher: PERGAMON-ELSEVIER SCIENCE LTD
Keywords: Network visualization, Visualization pipeline, Sensemaking loop, Visual analytics, Network analysis, Biological networks, State-of-the-art-report

Abstract

Biological networks describe complex relationships in biological systems, which represent biological entities as vertices and their underlying connectivity as edges. Ideally, for a complete analysis of such systems, domain experts need to visually integrate multiple sources of heterogeneous data, and visually, as well as numerically, probe said data in order to explore or validate (mechanistic) hypotheses. Such visual analyses require the coming together of biological domain experts, bioinformaticians, as well as network scientists to create useful visualization tools. Owing to the underlying graph data becoming ever larger and more complex, the visual representation of such biological networks has become challenging in its own right. This introduction and survey aims to describe the current state of biological network visualization in order to identify scientific gaps for visualization experts, network scientists, bioinformaticians, and domain experts, such as biologists, or biochemists, alike. Specifically, we revisit the classic visualization pipeline, upon which we base this paper’s taxonomy and structure, which in turn forms the basis of our literature classification. This pipeline describes the process of visualizing data, starting with the raw data itself, through the construction of data tables, to the actual creation of visual structures and views, as a function of task-driven user interaction. Literature was systematically surveyed using API-driven querying where possible, and the collected papers were manually read and categorized based on the identified sub-components of this visualization pipeline’s individual steps. From this survey, we highlight a number of exemplary visualization tools from multiple biological sub-domains in order to explore how they adapt these discussed techniques and why. Additionally, this taxonomic classification of the collected set of papers allows us to identify existing gaps in biological network visualization practices. We finally conclude this report with a list of open challenges and potential research directions. Examples of such gaps include (i) the overabundance of visualization tools using schematic or straight-line node-link diagrams, despite the availability of powerful alternatives, or (ii) the lack of visualization tools that also integrate more advanced network analysis techniques beyond basic graph descriptive statistics.

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BibTeX

@article{ehlers-2025-ait,
  title =      "An introduction to and survey of biological network
               visualization",
  author =     "Henry Ehlers and Nicolas Brich and Michael Krone and Martin
               N\"{o}llenburg and Jiacheng Yu and Hiroaki Natsukawa and
               Xiaoru Yuan and Hsiang-Yun Wu",
  year =       "2025",
  abstract =   "Biological networks describe complex relationships in
               biological systems, which represent biological entities as
               vertices and their underlying connectivity as edges.
               Ideally, for a complete analysis of such systems, domain
               experts need to visually integrate multiple sources of
               heterogeneous data, and visually, as well as numerically,
               probe said data in order to explore or validate
               (mechanistic) hypotheses. Such visual analyses require the
               coming together of biological domain experts,
               bioinformaticians, as well as network scientists to create
               useful visualization tools. Owing to the underlying graph
               data becoming ever larger and more complex, the visual
               representation of such biological networks has become
               challenging in its own right. This introduction and survey
               aims to describe the current state of biological network
               visualization in order to identify scientific gaps for
               visualization experts, network scientists,
               bioinformaticians, and domain experts, such as biologists,
               or biochemists, alike. Specifically, we revisit the classic
               visualization pipeline, upon which we base this paper’s
               taxonomy and structure, which in turn forms the basis of our
               literature classification. This pipeline describes the
               process of visualizing data, starting with the raw data
               itself, through the construction of data tables, to the
               actual creation of visual structures and views, as a
               function of task-driven user interaction. Literature was
               systematically surveyed using API-driven querying where
               possible, and the collected papers were manually read and
               categorized based on the identified sub-components of this
               visualization pipeline’s individual steps. From this
               survey, we highlight a number of exemplary visualization
               tools from multiple biological sub-domains in order to
               explore how they adapt these discussed techniques and why.
               Additionally, this taxonomic classification of the collected
               set of papers allows us to identify existing gaps in
               biological network visualization practices. We finally
               conclude this report with a list of open challenges and
               potential research directions. Examples of such gaps include
               (i) the overabundance of visualization tools using schematic
               or straight-line node-link diagrams, despite the
               availability of powerful alternatives, or (ii) the lack of
               visualization tools that also integrate more advanced
               network analysis techniques beyond basic graph descriptive
               statistics.",
  month =      feb,
  articleno =  "104115",
  doi =        "10.1016/j.cag.2024.104115",
  issn =       "1873-7684",
  journal =    "COMPUTERS & GRAPHICS-UK",
  pages =      "31",
  volume =     "126",
  publisher =  "PERGAMON-ELSEVIER SCIENCE LTD",
  keywords =   "Network visualization, Visualization pipeline, Sensemaking
               loop, Visual analytics, Network analysis, Biological
               networks, State-of-the-art-report",
  URL =        "https://www.cg.tuwien.ac.at/research/publications/2025/ehlers-2025-ait/",
}