Visual Analysis of Heart Reinervation after Transplantation

Roman Trobec, Kresimir Matkovic, Karolj Skala, Silvia Samarin, Matjaz Depolli, Viktor Avbelj
Visual Analysis of Heart Reinervation after Transplantation
In Proceedings of the MIPRO 2008. May 2008.
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Information

  • Publication Type: Conference Paper
  • Workgroup(s)/Project(s):
  • Date: May 2008
  • Booktitle: Proceedings of the MIPRO 2008
  • Lecturer: Roman Trobec
  • Location: Opatija, Croatia

Abstract

During heart transplantation complete denervation of allograft occurs. Partial reinnervation may develop after one year or later. It can be detected by different methods i.e., iodine- 123-meta-iodobenziylguanidine (MIBG) scintigraphy, positron emission tomography (PET), heart rate variability (HRV), etc. We propose an alternative noninvasive method based on visual diagnostics (VD) and supported by a custom developed tool (ComVis), which enables interactive visual analysis of large data sets by exploiting focus and context (simultaneous local and global view), multiple coordinated views and advanced interaction. Measurements of patients with transplanted heart are rare and valuable, therefore they should be analyzed in all details. Different statistical characteristics and time series from ECG and respiration measurements from fifteen patients and twelve healthy controls have been analyzed using the ComVis tool. MIBG scintigraphy imaging was included, as well. Heart to mediastinum ratio (HMR) was used as a measure of the ventricular reinervation. HRV was analyzed to evaluate sinus node reinnervation. HRV was synchronized on well defined expiration moment and analyzed in time-domain.We will describe some new diagnostic results or rules that were deduced from interactive visual analysis and may help in the future investigation of heart reinervation.

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BibTeX

@inproceedings{Trobec-2008-Heart,
  title =      "Visual Analysis of Heart Reinervation after Transplantation",
  author =     "Roman Trobec and Kresimir Matkovic and Karolj Skala and
               Silvia Samarin and Matjaz Depolli and Viktor Avbelj",
  year =       "2008",
  abstract =   "During heart transplantation complete denervation of
               allograft occurs. Partial reinnervation may develop after
               one year or later. It can be detected by different methods
               i.e., iodine- 123-meta-iodobenziylguanidine (MIBG)
               scintigraphy, positron emission tomography (PET), heart rate
               variability (HRV), etc. We propose an alternative
               noninvasive method based on visual diagnostics (VD) and
               supported by a custom developed tool (ComVis), which enables
               interactive visual analysis of large data sets by exploiting
               focus and context (simultaneous local and global view),
               multiple coordinated views and advanced interaction.
               Measurements of patients with transplanted heart are rare
               and valuable, therefore they should be analyzed in all
               details. Different statistical characteristics and time
               series from ECG and respiration measurements from fifteen
               patients and twelve healthy controls have been analyzed
               using the ComVis tool. MIBG scintigraphy imaging was
               included, as well. Heart to mediastinum ratio (HMR) was used
               as a measure of the ventricular reinervation. HRV was
               analyzed to evaluate sinus node reinnervation. HRV was
               synchronized on well defined expiration moment and analyzed
               in time-domain.We will describe some new diagnostic results
               or rules that were deduced from interactive visual analysis
               and may help in the future investigation of heart
               reinervation.",
  month =      may,
  booktitle =  "Proceedings of the MIPRO 2008",
  location =   "Opatija, Croatia",
  URL =        "/research/publications/2008/Trobec-2008-Heart/",
}