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        "tu_id": null,
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        "title": "An introduction to and survey of biological network visualization",
        "date": "2025-02",
        "abstract": "Biological networks describe complex relationships in biological systems, which represent biological entities as vertices and their underlying connectivity as edges. Ideally, for a complete analysis of such systems, domain experts need to visually integrate multiple sources of heterogeneous data, and visually, as well as numerically, probe said data in order to explore or validate (mechanistic) hypotheses. Such visual analyses require the coming together of biological domain experts, bioinformaticians, as well as network scientists to create useful visualization tools. Owing to the underlying graph data becoming ever larger and more complex, the visual representation of such biological networks has become challenging in its own right. This introduction and survey aims to describe the current state of biological network visualization in order to identify scientific gaps for visualization experts, network scientists, bioinformaticians, and domain experts, such as biologists, or biochemists, alike. Specifically, we revisit the classic visualization pipeline, upon which we base this paper’s taxonomy and structure, which in turn forms the basis of our literature classification. This pipeline describes the process of visualizing data, starting with the raw data itself, through the construction of data tables, to the actual creation of visual structures and views, as a function of task-driven user interaction. Literature was systematically surveyed using API-driven querying where possible, and the collected papers were manually read and categorized based on the identified sub-components of this visualization pipeline’s individual steps. From this survey, we highlight a number of exemplary visualization tools from multiple biological sub-domains in order to explore how they adapt these discussed techniques and why. Additionally, this taxonomic classification of the collected set of papers allows us to identify existing gaps in biological network visualization practices. We finally conclude this report with a list of open challenges and potential research directions. Examples of such gaps include (i) the overabundance of visualization tools using schematic or straight-line node-link diagrams, despite the availability of powerful alternatives, or (ii) the lack of visualization tools that also integrate more advanced network analysis techniques beyond basic graph descriptive statistics.",
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        "articleno": "104115",
        "doi": "10.1016/j.cag.2024.104115",
        "issn": "1873-7684",
        "journal": "COMPUTERS & GRAPHICS-UK",
        "pages": "31",
        "publisher": "PERGAMON-ELSEVIER SCIENCE LTD",
        "volume": "126",
        "research_areas": [
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            "NetVis"
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        "keywords": [
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            "Visualization pipeline",
            "Sensemaking loop",
            "Visual analytics",
            "Network analysis",
            "Biological networks",
            "State-of-the-art-report"
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        "tu_id": null,
        "repositum_id": "20.500.12708/205726",
        "title": "Me! Me! Me! Me! A study and comparison of ego network representations",
        "date": "2024-12",
        "abstract": "From social networks to brain connectivity, ego networks are a simple yet powerful approach to visualizing parts of a larger graph, i.e. those related to a selected focal node — the so-called “ego”. While surveys and comparisons of general graph visualization approaches exist in the literature, we note (i) the many conflicting results of comparisons of adjacency matrices and node-link diagrams, thus motivating further study, as well as (ii) the absence of such systematic comparisons for ego networks specifically. In this paper, we propose the development of empirical recommendations for ego network visualization strategies. First, we survey the literature across application domains and collect examples of network visualizations to identify the most common visual encodings, namely straight-line, radial, and layered node-link diagrams, as well as adjacency matrices. These representations are then applied to a representative, intermediate-sized network and subsequently compared in a large-scale, crowd-sourced user study in a mixed-methods analysis setup to investigate their impact on both user experience and performance. Within the limits of this study, and contrary to previous comparative investigations of adjacency matrices and node-link diagrams (outside of ego networks specifically), participants performed systematically worse when using adjacency matrices than those using node-link diagrammatic representations. Similar to previous comparisons of different node-link diagrams, we do not detect any notable differences in participant performance between the three node-link diagrams. Lastly, our quantitative and qualitative results indicate that participants found adjacency matrices harder to learn, use, and understand than node-link diagrams. We conclude that in terms of both participant experience and performance, a layered node-link diagrammatic representation appears to be the most preferable for ego network visualization purposes.",
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        "articleno": "104123",
        "doi": "10.1016/j.cag.2024.104123",
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        "publisher": "PERGAMON-ELSEVIER SCIENCE LTD",
        "volume": "125",
        "research_areas": [
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            "Ego network visualization",
            "Layered node-link diagram",
            "Radial node-link diagram",
            "Straight-line node-link diagram",
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        "type_id": "bachelorthesis",
        "tu_id": null,
        "repositum_id": null,
        "title": "Multidimensional Clustering for Machine Data Analysis",
        "date": "2024-07-11",
        "abstract": "Machine data analysis is an important aspect in modern industrial facilities, as stakeholders want their machinery to be as efficient as possible. To this end, they utilize the IIoT, enabling the analysis of gathered machine data. To gain useful information through the aggregated data, Big Data analytics are invaluable to the domain experts conducting\nmachine data analysis. The insights gained through Big Data analytics allow for a better efficiency of the facility by enabling data-driven decisions.\nThis thesis sets out to explore the feasibility of multidimensional clustering for machine data analysis in a web-based environment. To do this, we developed an application that\ncombines statistical methods and several visualization techniques into a web interface.\nWe evaluated the tool based on its real-world applicability and performance. The developed application has produced promising results, when employed on multivariate time series from industrial machinery, and thereby provides a robust foundation for future improvements.",
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        "date_start": "2023-11-11",
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    {
        "id": "ehlers-2024-vgs",
        "type_id": "inproceedings",
        "tu_id": null,
        "repositum_id": "20.500.12708/196069",
        "title": "Visualizing Group Structure in Compound Graphs: The Current State, Lessons Learned, and Outstanding Opportunities",
        "date": "2024-03-11",
        "abstract": "Compound graphs are common across domains, from social science to biochemical pathway studies, and their visualization is important to both their exploration and analysis. However, effectively visualizing a compound graph's topology and group structure requires careful consideration, as evident by the many different approaches to this particular problem. To better understand the current advancements in compound graph visualization, we have consolidated and streamlined existing surveys' taxonomies. More specifically, we aim to disentangle the visual relationship between graph topology and group structure from the visual encoding used to visualize its group structure in order to identify interesting gaps in the literature. In so doing, we are able to enumerate a number of lessons learned and gain a better understanding of the outstanding research opportunities and practical implications across domains.",
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        "booktitle": "Proceedings of the 19th International Joint Conference on Computer Vision, Imaging and Computer Graphics Theory and Applications - Volume 1, HUCAPP and IVAPP",
        "date_from": "2024-02-27",
        "date_to": "2024-02-29",
        "doi": "10.5220/0012431200003660",
        "event": "19th International Joint Conference on Computer Vision, Imaging and Computer Graphics Theory and Applications",
        "isbn": "978-989-758-679-8",
        "lecturer": [
            1850
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        "location": "Rom",
        "pages": "12",
        "pages_from": "697",
        "pages_to": "708",
        "research_areas": [
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            "NetVis"
        ],
        "keywords": [
            "compound graph visualization",
            "literature survey",
            "group structure visualization"
        ],
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        "id": "ehlers-2023-iro",
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        "tu_id": null,
        "repositum_id": "20.500.12708/192189",
        "title": "Improving readability of static, straight-line graph drawings: A first look at edge crossing resolution through iterative vertex splitting",
        "date": "2023-11",
        "abstract": "We present a novel vertex-splitting approach to iteratively resolve edge crossings in order to improve the readability of graph drawings. Dense graphs, even when small in size (10 to 15 nodes in size) quickly become difficult to read with increasing numbers of edges, and form so-called “hairballs”. The readability of a graph drawing is measured using many different quantitative aesthetic metrics. One such metric of particular importance is the number of edge crossings. Classical approaches to improving readability, such as the minimization of the number of edge crossings, focus on providing overviews of the input graph by aggregating or sampling vertices and/or edges. However, this simplification of the graph drawing does not allow for detailed views into the data, as not all vertices or edges are rendered, and also requires sophisticated interaction approaches to perform well. To avoid this, our locally optimal vertex splitting approach aims to minimize the number of remaining edge crossings while also minimizing the number of vertices that need to be split. In each iteration, we identify the vertex contributing the largest number of edge crossings, remove it, locate the embedding locations of said vertex's two split copies, and determine each copy's unique adjacency. We conduct a user study with 52 participants to evaluate whether vertex splitting affects users’ abilities to conduct a set of graph analytical tasks on graphs 12 nodes in size. Users were tasked with identifying a vertex's adjacency, determining the shared neighbors of two vertices, and checking the validity of a set of paths. We ultimately conclude that within the context of small, dense graphs, systematic vertex splitting is preferred by participants and even positively impacts user performance, though at the cost of the time taken per task.",
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        "doi": "10.1016/j.cag.2023.09.010",
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        "publisher": "PERGAMON-ELSEVIER SCIENCE LTD",
        "volume": "116",
        "research_areas": [
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        ],
        "keywords": [
            "Edge crossings",
            "Graph aesthetics",
            "Network visualization",
            "Vertex splitting"
        ],
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    {
        "id": "sorger-2021-egonet",
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        "tu_id": 300416,
        "repositum_id": "20.500.12708/58630",
        "title": "Egocentric Network Exploration for Immersive Analytics",
        "date": "2021-10",
        "abstract": "To exploit the potential of immersive network analytics for engaging and effective exploration, we promote the metaphor of ``egocentrism'', where data depiction and interaction are adapted to the perspective of the user within a 3D network. Egocentrism has the potential to overcome some of the inherent downsides of virtual environments, e.g., visual clutter and cyber-sickness. To investigate the effect of this metaphor on immersive network exploration, we designed and evaluated interfaces of varying degrees of egocentrism. In a user study, we evaluated the effect of these interfaces on visual search tasks, efficiency of network traversal, spatial orientation, as well as cyber-sickness. Results show that a simple egocentric interface considerably improves visual search efficiency and navigation performance, yet does not decrease spatial orientation or increase cyber-sickness. A distorted occlusion-free view of the neighborhood only marginally improves the user's performance. We tie our findings together in an open online tool for egocentric network exploration, providing actionable insights on the benefits of the egocentric network exploration metaphor.",
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        "publisher": "John Wiley and Sons",
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        "title": "Interactive exploration of large time-dependent bipartite graphs",
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        "abstract": "Bipartite graphs are typically visualized using linked lists or matrices, but these visualizations neither scale well nor do they convey temporal development. We present a new interactive exploration interface for large, time-dependent bipartite graphs. We use two clustering techniques to build a hierarchical aggregation supporting different exploration strategies. Aggregated nodes and edges are visualized as linked lists with nested time series. We demonstrate two use cases: finding advertising expenses of public authorities following similar temporal patterns and comparing author-keyword co-occurrences across time. Through a user study, we show that linked lists with hierarchical aggregation lead to more insights than without.",
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        "abstract": "During information foraging, knowledge workers iteratively seek, filter, read, and extract information. When using multiple information sources and different applications for information processing, re-examination of activities for validation of previous decisions or re-discovery of previously used information sources is challenging. In this paper, we present a novel representation of cross-application histories to support recall of past operations and re-discovery of information resources. Our graphical history consists of a cross-scale visualization combining an overview node-link diagram of used desktop resources with nested (animated) snapshot sequences, based on a recording of the visual screen output during the users’ desktop work. This representation makes key elements of the users’ tasks visually stand out, while exploiting the power of visual memory to recover subtle details of their activities. In a preliminary study, users found our graphical history helpful to recall details of an information foraging task and commented positively on the ability to expand overview nodes into snapshot and video sequences.",
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