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        "title": "Survey of the Visual Exploration and Analysis of Perfusion Data",
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        "title": "Application-Oriented Extensions of Profile Flags",
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        "abstract": "This paper discusses two applications of probing dense volumetric\r\ndata for MR orthopedics and dynamic contrast enhanced MRI\r\nmammography. In order not to reduce the context information and to\r\nextract the essential part of the data, we apply Profile Flags. A\r\nProfile Flag is a 3D glyph for probing and annotating the\r\nvolumetric data. The first application area deals with\r\nvisualization of T2 profiles for interactive inspection of knee\r\ncartilage and detection of lesions. In the second application, we\r\npresent the usability the Profile Flags for measuring of\r\ntime-signal profiles for a set of time-dependent MR volumes.\r\nSeveral extensions of the basic Profile Flag concept are described\r\nin detail and discussed. These extensions include selection of a\r\nset of profiles based on spatial as well as curve differences,\r\nautomatic positioning of the Profile Flags, and adaptation for\r\nprobing of time-varying volumetric data. Additionally, we include\r\nthe evaluation of the used methods by our medical partners.",
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        "title": "Medical Visualization for Orthopedic Applications",
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        "abstract": "This dissertation discusses visualization techniques of articular cartilage for\r\nboth quantitative and qualitative assessment. Articular cartilage is a very thin\r\nstructure covering the endings of human bones. Thus, even slight changes in its\r\nthickness and inner structure may indicate an occurrence or progress of degeneration.\r\nThe early detection of these factors is crucial for diagnosis and treatment of\r\ncartilage degeneration. Research to find treatments to stop or even reverse these\r\ndegenerative changes is well in progress.\r\nMagnetic resonance imaging is currently the best and most used non-invasive\r\ntechnique for acquisition of soft tissue structures like articular cartilage. In this\r\nwork we use two types of data: a high-resolution anatomical scan of the cartilage\r\nand a T2 map, which is computed from a set of sequences with varying parameters.\r\nWhile the thickness of the data can be precisely assessed fromthe anatomical scan,\r\nthe T2 map offers information on the inner structures of the cartilage.\r\nSince the femoral cartilage is a curved thin-wall structure with a relatively\r\nsmall extent in one direction, it is very difficult to estimate its thickness from a\r\nstack of slices or even from a three-dimensional reconstruction of its surface. We\r\ndiscuss inspection of the tissue by unfolding and, thus, representing the tissue as\r\na two-dimensional height field. Such a transformation of the object enables the\r\napplication of 2D geometrical operations in order to observe subtle details in the\r\nthickness of the tissue.\r\nNowadays scanners allow a quality assessment checking disruptions in the\r\npattern of the T2 map of the patellar cartilage. The T2 map illustrates the quality of\r\nthe cartilage and changes in the pattern of T2 map indicate defects before changes\r\nin the thickness itself occur. We propose the Profile Flags - an intuitive interface\r\nfor probing of the T2 maps by browsing the reconstructed surface of the cartilage.\r\nThe Profile Flag is positioned on the reconstructed surface of the tissue, and can\r\nbe moved along it. The Profile Flags can be applied to annotate local as well as\r\nglobal characteristics of the underlying data in a single still image. Furthermore,\r\nwe present a set of extensions to Profile Flags for selection, classification and\r\nautomatic positioning. Profile Flags can also be used to measure time-varying\r\ndynamic contrast enhanced magnetic resonance imaging data.",
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        "title": "Profile Flags: a Novel Metaphor for Probing of T2 Maps",
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        "abstract": "This paper describes a tool for the visualization of T2 maps of knee cartilage. Given the anatomical scan and the T2 map of the cartilage, we combine the information on the shape and the quality of the cartilage in a single image. The Profile Flag is an intuitive 3D glyph for probing and annotating of the underlying data. It comprises a bulletin board pin-like shape with a small flag on top of it. While moving the glyph along the reconstructed surface of an object, the curve data measured along the pin's needle and in its neighborhood are shown on the flag. The application area of the Profile Flag is manifold, enabling the visualization of profile data of dense but inhomogeneous objects. Furthermore, it extracts the essential part of the data without removing or even reducing the context information. By sticking Profile Flags into the investigated structure, one or more significant locations can be annotated by showing the local characteristics of the data at that locations. In this paper we are demonstrating the properties of the tool by visualizing T2 maps of knee cartilage.",
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        "title": "Interactive Thickness Visualization of Articular Cartilage",
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        "abstract": "This paper describes a method to visualize the thickness of curved\r\nthin objects. Given the MRI volume data of articular cartilage,\r\nmedical doctors investigate pathological changes of the thickness.\r\nSince the tissue is very thin, it is impossible to reliably map\r\nthe thickness information by direct volume rendering. Our idea is\r\nbased on unfolding of such structures preserving their thickness.\r\nThis allows to perform anisotropic geometrical operations (e.g.,\r\nscaling the thickness). However, flattening of a curved structure\r\nimplies a distortion of its surface. The distortion problem is\r\nalleviated through a focus-and-context minimization approach.\r\nDistortion is smallest close to a focal point which can be\r\ninteractively selected by the user.",
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