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        "title": "Flattening-based visualization of supine breast MRI",
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        "abstract": "We propose two novel visualization methods optimized for supine breast images that “flatten” breast tissue, facilitating examination of larger tissue areas within each coronal slice. Breast cancer is the most frequently diagnosed cancer in women, and early lesion detection is crucial for reducing mortality. Supine breast magnetic resonance imaging (MRI) enables better lesion localization for image-guided interventions; however, traditional axial visualization is suboptimal because the tissue spreads over the chest wall, resulting in numerous fragmented slices that radiologists must scroll through during standard interpretation. Using a human-centered design approach, we incorporated user and expert feedback throughout the co-design and evaluation stages of our flattening methods. Our first proposed method, a surface-cutting approach, generates offset surfaces and flattens them independently using As-Rigid-As-Possible (ARAP) surface mesh parameterization. The second method uses a landmark-based warp to flatten the entire breast volume at once. Expert evaluations revealed that the surface-cutting method provides intuitive overviews and clear vascular detail, with low metric (2–2.5%) and area (3.7–4.4%) distortions. However, independent slice flattening can introduce depth distortions across layers. The landmark warp offers consistent slice alignment and supports direct annotations and measurements, with radiologists favoring it for its anatomical accuracy. Both methods significantly reduced the number of slices needed to review, highlighting their potential for time savings and clinical impact — an essential factor for adopting supine MRI.",
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        "title": "Spatial-Data-Driven Layouting for Brain Network Visualization",
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        "abstract": "Recent advances in neuro-imaging enable scientists to create brain network data that can lead to novel insights into neurocircuitry, and a better understanding of the brain’s organization. These networks inherently involve a spatial component, depicting which brain regions are structurally, functionally or genetically related. Their visualization in 3D suffers from occlusion and clutter, especially with increasing number of nodes and connections, while 2D representations such as connectograms, connectivity matrices, and node-link diagrams neglect the spatio-anatomical context. Approaches to arrange 2D-graphs manually are tedious, species-dependent, and require the knowledge of domain experts.\r\nIn this paper, we present a spatial-data-driven approach for layouting 3D brain networks in 2D node-link diagrams, while maintaining their spatial organization. The produced graphs do not need manual positioning of nodes, are consistent (even for sub-graphs), and provide a perspective-dependent arrangement for orientation. Furthermore, we provide a visual design for highlighting anatomical context, including the shape of the brain, and the size of brain regions. We present in several case-studies the applicability of our approach for different neuroscience-relevant species, including the mouse, human, and Drosophila larvae. In a user study conducted with several domain experts, we demonstrate its relevance and validity, as well as its potential for neuroscientific publications, presentations, and education.",
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        "repositum_id": "20.500.12708/141135",
        "title": "The moving target of visualization software for an increasingly complex world",
        "date": "2020-04",
        "abstract": "Visualization has evolved into a mature scientific field and it has also become widely accepted as a standard approach in diverse fields, including physics, life sciences, and business intelligence. However, despite its successful development, there are still many open research questions that require customized implementations in order to explore and establish concepts, and to perform experiments and take measurements. Many methods and tools have been developed and published but most are stand-alone prototypes and have not reached a mature state that can be used in a reliable manner by collaborating domain scientists or a wider audience. In this study, we discuss the challenges, solutions, and open research questions that affect the development of sophisticated, relevant, and novel scientific visualization solutions with minimum overheads. We summarize and discuss the results of a recent National Institute of Informatics Shonan seminar on these topics.",
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        "title": "Principles of Visualization in Radiation Oncology",
        "date": "2020-01-15",
        "abstract": "Background: Medical visualization employs elements from computer graphics to create meaningful, interactive visual representations of medical data, and it has become an influential field of research for many advanced applications like radiation oncology, among others. Visual representations employ the user’s cognitive capabilities to support and accelerate diagnostic, planning, and quality assurance workflows based on involved patient data. Summary: This article discusses the basic underlying principles of visualization in the application domain of radiation oncology. The main visualization strategies, such as slice-based representations and surface and volume rendering are presented. Interaction topics, i.e., the combination of visualization and automated analysis methods, are also discussed. Key Messages: Slice-based representations are a common approach in radiation oncology, while volume visualization also has a long-standing history in the field. Perception within both representations can benefit further from advanced approaches, such as image fusion and multivolume or hybrid rendering. While traditional slice-based and volume representations keep evolving, the dimensionality and complexity of medical data are also increasing. To address this, visual analytics strategies are valuable, particularly for cohort or uncertainty visualization. Interactive visual analytics approaches represent a new opportunity to integrate knowledgeable experts and their cognitive abilities in exploratory processes which cannot be conducted by solely automatized methods.",
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        "title": "State-of-the-Art Report: Visual Computing in Radiation Therapy Planning",
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        "abstract": "Radiation therapy (RT) is one of the major curative approaches for cancer. It is a complex and risky treatment approach, which\nrequires precise planning, prior to the administration of the treatment. Visual Computing (VC) is a fundamental component of\nRT planning, providing solutions in all parts of the process—from imaging to delivery. Despite the significant technological\nadvancements of RT over the last decades, there are still many challenges to address. This survey provides an overview of\nthe compound planning process of RT, and of the ways that VC has supported RT in all its facets. The RT planning process\nis described to enable a basic understanding in the involved data, users and workflow steps. A systematic categorization and\nan extensive analysis of existing literature in the joint VC/RT research is presented, covering the entire planning process. The\nsurvey concludes with a discussion on lessons learnt, current status, open challenges, and future directions in VC/RT research.",
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        "title": "neuroMAP - Interactive Graph-Visualization of the Fruit Fly's Neural Circuit",
        "date": "2013-10",
        "abstract": "Neuroscientists study the function of neural circuits in the brain of the common fruit fly Drosophila melanogaster to discover how complex behavior is generated. To establish models of neural information processing, knowledge about potential connections between individual neurons is required. Connections can occur when the arborizations of two neurons overlap. Judging connectivity by analyzing overlaps using traditional volumetric visualization is difficult since the examined objects occlude each other. A more abstract form of representation is therefore desirable. In collaboration with a group of neuroscientists, we designed and implemented neuroMap, an interactive two-dimensional graph that renders the brain and its interconnections in the form of a circuit-style wiring diagram. neuroMap provides a clearly structured overview of all possible connections between neurons and offers means for interactive exploration of the underlying neuronal database. In this paper, we discuss the design decisions that formed neuroMap and evaluate its application in discussions with the scientists.",
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        "title": "Eurographics Tutorial on Illustrative Visualization",
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        "id": "Buehler-2003-Geo",
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        "abstract": "Visualization and quantitative analysis of vessel data is an important preprocessing step in diagnosis of vascular diseases, monitoring, surgery planning, blood flow simulation, education and training surgeons. This paper surveys several geometric methods to solve basic visualization and quantification problems like centerline computation, boundary detection, projections techniques, and geometric model generation.",
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        "title": "Implicit Linear Interval Estimations",
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        "title": "Fast and Reliable Plotting of Implicit Curves",
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