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        "id": "Mistelbauer_2021",
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        "title": "Semi-automatic vessel detection for challenging cases of peripheral arterial disease ",
        "date": "2021-03-18",
        "abstract": "Objectives: Manual or semi-automated segmentation of the lower extremity arterial tree in patients with Pe-ripheral arterial disease (PAD) remains a notoriously difﬁcult and time-consuming task. The complex manifes-tations of the disease, including discontinuities of the vascular ﬂow channels, the presence of calciﬁed atherosclerotic plaque in close vicinity to adjacent bone, and the presence of metal or other imaging artifacts currently preclude fully automated vessel identiﬁcation. New machine learning techniques may alleviate this challenge, but require large and reasonably well segmented training data. \nMethods: We propose a novel semi-automatic vessel tracking approach for peripheral arteries to facilitate and accelerate the creation of annotated training data by expert cardiovascular radiologists or technologists, while limiting the number of necessary manual interactions, and reducing processing time. After automatically clas-sifying blood vessels, bones, and other tissue, the relevant vessels are tracked and organized in a tree-like structure for further visualization. \nResults: We conducted a pilot (N = 9) and a clinical study (N = 24) in which we assess the accuracy and required time for our approach to achieve sufﬁcient quality for clinical application, with our current clinically established workﬂow as the standard of reference. Our approach enabled expert physicians to readily identify all clinically relevant lower extremity arteries, even in problematic cases, with an average sensitivity of 92.9%, and an average speciﬁcity and overall accuracy of 99.9%. \nConclusions: Compared to the clinical workﬂow in our collaborating hospitals (28:40 ± 7:45 [mm:ss]), our approach (17:24 ± 6:44 [mm:ss]) is on average 11:16 [mm:ss] (39%) faster.   ",
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        "doi": "10.1016/j.compbiomed.2021.104344",
        "first_published": "2021-03-18",
        "journal": "Computers in Biology and Medicine ",
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    {
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        "title": "Visual Analytics in Dental Aesthetics",
        "date": "2020",
        "abstract": "Dental healthcare increasingly employs computer-aided design software,\nto provide patients with high-quality dental prosthetic devices. In\nmodern dental reconstruction, dental technicians address the unique\nanatomy of each patient individually, by capturing the dental impression\nand measuring the mandibular movements. Subsequently, dental technicians\ndesign a custom denture that fits the patient from a functional point of\nview. The current workflow does not include a systematic analysis of\naesthetics, and dental technicians rely only on an aesthetically\npleasing mock-up that they discuss with the patient, and on their\nexperience. Therefore, the final denture aesthetics remain unknown until\nthe dental technicians incorporate the denture into the patient. In this\nwork, we present a solution that integrates aesthetics analysis into the\nfunctional workflow of dental technicians. Our solution uses a video\nrecording of the patient, to preview the denture design at any stage of\nthe denture design process. We present a teeth pose estimation technique\nthat enables denture preview and a set of linked visualizations that\nsupport dental technicians in the aesthetic design of dentures. These\nvisualizations assist dental technicians in choosing the most\naesthetically fitting preset from a library of dentures, in identifying\nthe suitable denture size, and in adjusting the denture position. We\ndemonstrate the utility of our system with four use cases, explored by a\ndental technician. Also, we performed a quantitative evaluation for\nteeth pose estimation, and an informal usability evaluation, with\npositive outcomes concerning the integration of aesthetics analysis into\nthe functional workflow.",
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        "authors": [
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            660,
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        "doi": "https://doi.org/10.1111/cgf.14174",
        "journal": "Computer Graphics Forum",
        "number": "7",
        "pages": "635–646",
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        "volume": "39",
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        "keywords": [
            "Applied computing -> Life and medical sciences",
            "Human-centered computing -> Visualization application domains"
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    {
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        "title": "ManyLands: A Journey Across 4D Phase Space of Trajectories",
        "date": "2019-10",
        "abstract": "Mathematical models of ordinary differential equations are used to describe and understand biological phenomena. These models are dynamical systems that often describe the time evolution of more than three variables, i.e., their dynamics take place in a multi-dimensional space, called the phase space. Currently, mathematical domain scientists use plots of typical trajectories in the phase space to analyze the qualitative behavior of dynamical systems. These plots are called phase portraits and they perform well for 2D and 3D dynamical systems. However, for 4D, the visual exploration of trajectories becomes challenging, as simple subspace juxtaposition is not sufficient. We propose ManyLands to support mathematical domain scientists in analyzing 4D models of biological systems. By describing the subspaces as Lands, we accompany domain scientists along a continuous journey through 4D HyperLand, 3D SpaceLand, and 2D FlatLand, using seamless transitions. The Lands are also linked to 1D TimeLines. We offer an additional dissected view of trajectories that relies on small-multiple compass-alike pictograms for easy navigation across subspaces and trajectory segments of interest. We show three use cases of 4D dynamical systems from cell biology and biochemistry. An informal evaluation with mathematical experts confirmed that ManyLands helps them to visualize and analyze complex 4D dynamics, while facilitating mathematical experiments and simulations.",
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        "date_from": "2019-01-01",
        "date_to": "2019-06-07",
        "doi": "10.1111/cgf.13828",
        "event": "Pacific Graphics 2019",
        "journal": "Computer Graphics Forum",
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        "location": "Seoul, South Korea",
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        "pages_from": "191",
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        "volume": "38",
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    {
        "id": "manylands_award",
        "type_id": "unknown",
        "tu_id": null,
        "repositum_id": null,
        "title": "EG VCBM 2019 Image Contest Award, people's choice—ManyLands: A Journey Across 4D Phase Space of Biological Systems",
        "date": "2019",
        "abstract": null,
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    {
        "id": "Schernthaner-2017-MCP",
        "type_id": "journalpaper_notalk",
        "tu_id": null,
        "repositum_id": null,
        "title": "Multipath Curved Planar Reformations of Peripheral CT Angiography: Diagnostic Accuracy and Time Efficiency",
        "date": "2018-05-01",
        "abstract": "Objectives To compare diagnostic performance and time\nefficiency between 3D multipath curved planar reformations\n(mpCPRs) and axial images of CT angiography for\nthe pre-interventional assessment of peripheral arterial\ndisease (PAD), with digital subtraction angiography as the\nstandard of reference.\nMethods Forty patients (10 females, mean age 72 years),\nreferred to CTA prior to endovascular treatment of PAD,\nwere prospectively included and underwent peripheral CT\nangiography. A semiautomated toolbox was used to render\nmpCPRs. Twenty-one arterial segments were defined in\neach leg; for each segment, the presence of stenosis[70%\nwas assessed on mpCPRs and axial images by two readers,\nindependently, with digital subtraction angiography as gold\nstandard.\nResults Both readers reached lower sensitivity (Reader 1:\n91 vs. 94%, p = 0.08; Reader 2: 89 vs. 93%, p = 0.03) but\nsignificantly higher specificity (Reader 1: 94 vs. 89%,\np\\0.01; Reader 2: 96 vs. 95%, p = 0.01) with mpCPRs\nthan with axial images. Reader 1 achieved significantly\nhigher accuracy with mpCPRs (93 vs. 91%, p = 0.02), and Reader 2 had similar overall accuracy in both evaluations\n(94 vs. 94%, p = 0.96). Both readers read mpCPRs significantly\nfaster than axial images (Reader 1: 504500 based\non mpCPRs vs. 704000 based on axial images; Reader 2:\n404100 based on mpCPRs vs. 605700 based on axial images;\np\\0.01).\nConclusions mpCPRs are a promising 3D reformation\ntechnique that facilitates a fast assessment of PAD with\nhigh diagnostic accuracy.",
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        "doi": "10.1007/s00270-017-1846-3",
        "issn": "0174-1551",
        "journal": "CardioVascular and Interventional Radiology",
        "number": "5",
        "pages_from": "718",
        "pages_to": "725",
        "volume": "41",
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        "keywords": [
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            "CTA",
            "3D reformation",
            "mpCPRs"
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    {
        "id": "mindek-2017-dsn",
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        "title": "Data-Sensitive Visual Navigation",
        "date": "2017-10",
        "abstract": "In visualization systems it is often the case that the changes of the input parameters are not proportional to the visual change of the generated output. In this paper, we propose a model for enabling data-sensitive navigation for user-interface elements. This model is applied to normalize the user input according to the visual change, and also to visually communicate this normalization. In this way, the exploration of heterogeneous data using common interaction elements can be performed in an efficient way. We apply our model to the field of medical visualization and present guided navigation tools for traversing vascular structures and for camera rotation around 3D volumes. The presented examples demonstrate that the model scales to user-interface elements where multiple parameters are set simultaneously.",
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        "date_from": "2017-05-15",
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        "abstract": "The identification of dissimilar regions in spatial and temporal data is a fundamental part of data exploration.\nThis process takes place in applications, such as biomedical image processing as well as climatic data analysis.\nWe propose a general solution for this task by employing well-founded statistical tools.\nFrom a large set of candidate regions, we derive an empirical distribution of the data and perform statistical hypothesis testing to obtain p-values as measures of dissimilarity.\nHaving p-values, we quantify differences and rank regions on a global scale according to their dissimilarity to user-specified exemplar regions.\nWe demonstrate our approach and its generality with two application scenarios, namely interactive exploration of climatic data and segmentation editing in the medical domain.\nIn both cases our data exploration protocol unifies the interactive data analysis, guiding the user towards regions with the most relevant dissimilarity characteristics.\nThe dissimilarity analysis results are conveyed with a radial tree, which prevents the user from searching exhaustively through all the data.",
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        "title": "Visual Quantification of the Circle of Willis: An Automated Identification and Standardized Representation",
        "date": "2016",
        "abstract": "This paper presents a method for the visual quantification of cerebral arteries, known as the Circle of Willis (CoW). It is an arterial structure with the responsibility of supplying the brain with blood, however, dysfunctions can lead to strokes. The diagnosis of such a time-critical/urgent event depends on the expertise of radiologists and the applied software tools. They use basic display methods of the volumetric data without any support of advanced image processing and visualization techniques. The goal of this paper is to present an automated method for the standardized description of cerebral arteries in stroke patients in order to provide an overview of the CoW's configuration. This novel representation provides visual indications of problematic areas as well as straightforward comparisons between multiple patients. Additionally, we offer a pipeline for extracting the CoW from Time-of-Flight Magnetic Resonance Angiography (TOF-MRA) data sets together with an enumeration technique for labelling the arterial segments by detecting the main supplying arteries of the CoW. We evaluated the feasibility of our visual quantification approach in a study of 63 TOF-MRA data sets and compared our findings to those of three radiologists. The obtained results demonstrate that our proposed techniques are effective in detecting the arteries and visually capturing the overall configuration of the CoW.",
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        "title": "CoWRadar: Visual Quantification of the Circle of Willis in Stroke Patients",
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        "abstract": "This paper presents a method for the visual quantification of cerebral arteries, known as the Circle of Willis (CoW).\nThe CoW is an arterial structure that is responsible for the brain’s blood supply. Dysfunctions of this arterial circle\ncan lead to strokes. The diagnosis relies on the radiologist’s expertise and the software tools used. These tools\nconsist of very basic display methods of the volumetric data without support of advanced technologies in medical\nimage processing and visualization. The goal of this paper is to create an automated method for the standardized\ndescription of cerebral arteries in stroke patients in order to provide an overview of the CoW’s configuration. This novel display provides visual indications of problematic areas as well as straightforward comparisons between\nmultiple patients. Additionally, we offer a pipeline for extracting the CoW from Time-of-Flight Magnetic Resonance\nAngiography (TOF-MRA) data sets. An enumeration technique for the labeling of the arterial segments is therefore\nsuggested. We also propose a method for detecting the CoW’s main supplying arteries by analyzing the coronal,\nsagittal and transverse image planes of the data sets. We evaluated the feasibility of our visual quantification\napproach in a study of 63 TOF-MRA data sets and compared our findings to those of three radiologists. The obtained results demonstrate that our proposed techniques are effective in detecting the arteries of the CoW.",
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    {
        "id": "Mistelbauer_Gabriel_2015_NHR",
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        "repositum_id": null,
        "title": "New hybrid reformations of peripheral CT angiography: do we still need axial images?",
        "date": "2015-07",
        "abstract": "Purpose\r\n\r\nTo quantify the detectability of peripheral artery stenosis on hybrid CT angiography (CTA) reformations.\r\nMethods\r\n\r\nHybrid reformations were developed by combining multipath curved planar reformations (mpCPR) and maximum intensity projections (MIP). Fifty peripheral CTAs were evaluated twice: either with MIP, mpCPR and axial images or with hybrid reformations only. Digital subtraction angiography served as gold standard.\r\nResults\r\n\r\nUsing hybrid reformations, two independent readers detected 88.0% and 81.3% of significant stenosis, respectively. However, CTA including axial images detected statistically significant more lesions (98%).\r\nConclusion\r\n\r\nPeripheral CTA reading including axial images is still recommended. Further improvement of these hybrid reformations is necessary.",
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