Multi-Scale Procedural Animations of Microtubule Dynamics Based on Measured Data

Tobias Klein, Ivan Viola, Meister Eduard Gröller, Peter Mindek
Multi-Scale Procedural Animations of Microtubule Dynamics Based on Measured Data
IEEE Transactions on Visualization and Computer Graphics, 2019.

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Abstract

Biologists often use computer graphics to visualize structures, which due to physical limitations are not possible to image with a microscope. One example for such structures are microtubules, which are present in every eukaryotic cell. They are part of the cytoskeleton maintaining the shape of the cell and playing a key role in the cell division. In this paper, we propose a scientificallyaccurate multi-scale procedural model of microtubule dynamics as a novel application scenario for procedural animation, which can generate visualizations of their overall shape, molecular structure, as well as animations of the dynamic behaviour of their growth and disassembly. The model is spanning tens of micrometers down to atomic resolution. All the aspects of the model are driven by scientific data. The advantage over a traditional, manual animation approach is that when the underlying data change, for instance due to new evidence, the model can be recreated immediately. The procedural animation concept is presented in its generic form, with several novel extensions, allowing an easy translation to other domains with emergent multi-scale behavior.

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BibTeX

@article{klein_2019_PM,
  title =      "Multi-Scale Procedural Animations of Microtubule Dynamics
               Based on Measured Data",
  author =     "Tobias Klein and Ivan Viola and Meister Eduard Gr\"{o}ller
               and Peter Mindek",
  year =       "2019",
  abstract =   "Biologists often use computer graphics to visualize
               structures, which due to physical limitations are not
               possible to image with a microscope. One example for such
               structures are microtubules, which are present in every
               eukaryotic cell. They are part of the cytoskeleton
               maintaining the shape of the cell and playing a key role in
               the cell division. In this paper, we propose a
               scientificallyaccurate multi-scale procedural model of
               microtubule dynamics as a novel application scenario for
               procedural animation, which can generate visualizations of
               their overall shape, molecular structure, as well as
               animations of the dynamic behaviour of their growth and
               disassembly. The model is spanning tens of micrometers down
               to atomic resolution. All the aspects of the model are
               driven by scientific data. The advantage over a traditional,
               manual animation approach is that when the underlying data
               change, for instance due to new evidence, the model can be
               recreated immediately. The procedural animation concept is
               presented in its generic form, with several novel
               extensions, allowing an easy translation to other domains
               with emergent multi-scale behavior.",
  journal =    "IEEE Transactions on Visualization and Computer Graphics",
  URL =        "https://www.cg.tuwien.ac.at/research/publications/2019/klein_2019_PM/",
}