Following recent advances in GPU hardware development and newly introduced rendering pipeline extensions, the segmentation of input geometry into small geometry clusters—so-called meshlets—has emerged as an important practice for efficient rendering of complex 3D models. Meshlets can be processed efficiently using mesh shaders on modern graphics processing units, in order to achieve streamlined geometry processing in just two tightly coupled shader stages that allow for dynamic workload manipulation in-between. The additional granularity layer between entire models and individual triangles enables new opportunities for fine-grained visibility culling methods. However, in contrast to static models, view frustum and backface culling on a per-meshlet basis for skinned, animated models are difficult to achieve while respecting the conservative spatio-temporal bounds that are required for robust rendering results. In this paper, we describe a solution for computing and exploiting relevant conservative bounds for culling meshlets of models that are animated using linear blend skinning. By enabling visibility culling for animated meshlets, our approach can help to improve rendering performance and alleviate bottlenecks in the notoriously performance-and memory-intensive skeletal animation pipelines of modern real-time graphics applications.